In primary aldosteronism (Conn Syndrome), what is the expected level of aldosterone?

In primary aldosteronism, also known as Conn Syndrome, there is an overproduction of aldosterone due to adrenal gland abnormalities, usually resulting from an adrenal adenoma or bilateral adrenal hyperplasia. This condition leads to excessive aldosterone secretion, regardless of the body's physiological needs for sodium and blood pressure regulation. Consequently, the expected level of aldosterone in patients with primary aldosteronism is typically high.

The high levels of aldosterone result in increased sodium retention, potassium excretion, and fluid retention, contributing to hypertension and electrolyte imbalances characteristic of the disease. This elevated aldosterone disrupts normal feedback mechanisms, leading to further hormonal dysfunction and associated symptoms.